About 30 results found for searched term "NG 52" (0.096 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13608 | NG 52 | CDK |
| Compound 52 | ||
| NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. | ||
| M2885 | NMS-E973 | HSP |
| NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. | ||
| M4058 | 11-oxo-mogroside-V | ROS |
| 11-Oxo-Mogroside V is a natural sweetener with strong antioxidant activity. 11-OXo-Mogroside V had a significant inhibitory effect on reactive oxygen species, and the EC50 of O2-, H2O2 and *OH were 4.79, 16.52 and 146.17 μg/mL, respectively. | ||
| M4357 | 3-Isomangostin | DNA/RNA Synthesis |
| 3 - Isomangostin from Garciniamangostana. L. Extracted from shell, 3-isomangostin is an effective MutT homolog 1 (MTH1) inhibitor with IC50 value of 52 nM. 3-Isomangostin can be used to develop anticancer agents. | ||
| M5117 | CFSE (CFDA-SE) | Fluorescent Dye |
| 5(6)-CFDA N-succinmidyl ester | ||
| Succinimide (CFSE) is a luciferase - based tracer that penetrates and immobilizes cells for extremely long-term cell labeling. The maximum excitation/emission wavelength is 494nm/521 nm. Fluorescent green. Store away from light. | ||
| M8301 | MJC13 | Others |
| MJC13 inhibits the positive regulation of androgen receptor (AR) signaling by the cochaperone protein FKBP52. | ||
| M8619 | ASMI | Others |
| ASMI is a cell-permeable, non-toxic, biocompatible, photostable, positively charged, mitochondria targeting styryl-methylpyridinium based compound that acts as a rapid, cysteine selective, sensitive, and ratiometric (F 518 /F 452 nm) fluorescent turn-on probe (0. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M9724 | JC-1 | Fluorescent Dye |
| CBIC2; NK 1420 | ||
| Jc-1 (Mitochondrial membrane potential probe) is a fluorescent lipophilic carbonyl cyanine dye used to measure mitochondrial membrane potential. The maximum excitation/emission wavelength is 515nm/529nm (590nm), and green fluorescence is emitted. Used to observe mitochondria, stored at room temperature, away from light. | ||
| M10107 | Longdaysin | Casein Kinase |
| Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7. | ||
| M10676 | Tegoprazan | ATPase |
| CJ-12420; IN-A001; LXI-15028 | ||
| Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028) is a potassium-competitive acid blocker and a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. | ||
| M11514 | Hoechst 33258 | Fluorescent Dye |
| H 33258 | ||
| Hoechst 33258 (dibiphenimide) can bind dsDNA, with a maximum excitation/emission wavelength of 352 nm/461 nm (after binding with DNA), giving blue fluorescence, which is often used to observe the nucleus and nucleic acid. Store at room temperature away from light. | ||
| M11520 | Acridine Orange 10-Nonyl Bromide | Fluorescent Dye |
| Acridine Orange 10-nonyl Bromide is a fluorescent probe binding to cardiolipin in mitochondria. The ranging wavelength is 495 nm/521nm. Storage at room temperature and away from light. | ||
| M11523 | Rhodamine 6G | Fluorescent Dye |
| Basic Red 1；Rhodamine 590；R6G | ||
| Rhodamine 6G (Rhodamine 6G) is a fluorescent tracer that can bind to mitochondria, with a maximum excitation/emission wavelength of 525nm/550nm. It emits orange-red fluorescence and should be stored away from light. | ||
| M13406 | Deacetylase Inhibitor Cocktail (100X) | Inhibitor Cocktails |
| AbMole Deacetylase Inhibitor Cocktail is a synergistic combination of chemicals designed to preserve the acetylation state of proteins. AbMole Deacetylase Inhibitor Cocktail (100X) is provided as 1 mL vial. Each vial contains 1 mL 70% DMSO with the following components: Trichostatin A (40 μM), EX-527 (1 mM), Nicotinamide (400 mM), and Sodium Butyrate (200 mM). | ||
| M15087 | Recombinant Human Wnt3a (E. coli) | Recombinant Proteins |
| MGC119418; MGC119419; MGC119420 | ||
| Recombinant human WnT-3A protein was produced by Escherichia coli expression system. The DNA sequence encoding human WNT3A (Ser19-Lys352) was fused to the His tag. Accession # P56704. | ||
| M19397 | Vicenin1 | ACE |
| Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM). | ||
| M19993 | Recombinant Human B4GALT1 (Mammalian, C-6His) | Recombinant Proteins |
| 1,4- galactosyltransferase, polypeptide 1; B4GalT1 | ||
| Recombinant human β-1, 4-galactosyl transferase 1 is produced by the mammalian expression system, and the target gene encodes Gly44-Ser398(Tyr285Leu) expressing the 6His tag at the C-terminus. Protein number: P15291. | ||
| M21154 | NRX-252114 | Others |
| NRX-25211 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-25211 was able to promote the degradation of mutant β catenin degradation. | ||
| M21174 | Ledaborbactam etzadroxil | Others |
| VNRX-7145 | ||
| Serine_lactamase inhibitor VNRX-7145 is an oral biologic formulation of the boronic acid-containing inhibitor VNRX-5236, currently in Phase I. | ||
| M21335 | Fluo-5N,AM | Fluorescent Dye |
| Calcium fluorescent probe Fluo-5N,AM is a calcium fluorescent probe, Fluo-5N is an analog of Fluo-4 with a low calcium binding affinity (Kd = ~90 uM), making it suitable for detecting intracellular calcium levels in the range of 1 μM to 1 mM, which would saturate the Fluo-4 response. The optimal excitation/emission wavelength is 490 nm/525 nm. | ||
| M21344 | Recombinant Human CXCL16 (Val52-Lys190) (E.coli) | Recombinant Proteins |
| C-X-C motif chemokine 16 | ||
| Protein Construct: DNA sequence encoding human CXCL16 (Val52-Lys190) fused to a His tag. Accession #: Q9H2A7. | ||
| M21573 | Recombinant Human/Cynomolgus CD28 (Mammalian, N-6His) | Recombinant Proteins |
| CD28; CD28 antigen; CD28 molecule | ||
| Recombinant human t cell specific surface glycoprotein CD28 is produced by mammalian expression systems, and the target gene encoding Asn19-Pro152 is expressed in the N-terminal with the 6His tag. Protein number: P10747. | ||
| M21709 | 5-FAM | Fluorescent Dye |
| 5-Carboxyfluorescein | ||
| 5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm. | ||
| M21722 | Felezonexor (CBS9106) | CRM1 |
| CBS9106; SL-801 | ||
| Felezonexor (CBS9106; SL-801) is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity without affecting CRM1 mRNA levels. Felezonexor is also a reversible inhibitor of XPO1, inhibits nuclear export by covalently binding to Cys528 as well as by inducing the degradation of XPO1. | ||
| M22485 | Recombinant Human CD14 (Mammalian, C-6His) | Recombinant Proteins |
| Monocyte Differentiation Antigen CD14 | ||
| Recombinant Human CD14 is produced by Mammalian expression system and the target gene encoding Thr20-Cys352 is expressed with a 6His tag at the C-terminus. CD14 is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. | ||
| M24956 | Cendakimab | IL Receptor/Related |
| RPC 4046; ABT 308; CC-93538 | ||
| Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. | ||
| M25392 | GSHtracer | Others |
| GSHtracer is a ratiometric probe for measuring of GSH levels. GSHtracer exhibits Ex/Em from 520/580 nm to 430/510 nm (upon GSH binding). | ||
| M25542 | JNJ-5207787 | Neuropeptide Receptor |
| JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50 values of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors. | ||
| M27624 | Amastatin hydrochloride | Aminopeptidase |
| Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase. | ||
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